Directed by Professor Yvan Guindon, this laboratory is working on development of new synthetic methodologies for the elaboration of new stereogenic centers on acyclic substrates, which are considered to be among the most difficult chemical entities to modify diastereoselectively due to the lack of rigidity in their structure. Ultimately, the goal of this research is to derive unique and complementary tools for the synthesis of biologically interesting complex molecules that can be used for elucidating the different mechanisms associated with various pathologies. This research unit is also interested in the design and synthesis of selective selectin ligands that could serve as therapeutic agents in the control of inflammation and/or cancer. Cellular adhesion phenomena related to selectins are studied in vitro, and new, more sophisticated biophysical methodologies are being developed. Also in progress is a new versatile and convergent approach to the synthesis of nucleoside analogues.
Graduate students of the Bioorganic Chemistry research unit are enrolled in the Graduate program in the Department of Chemistry at the Université de Montréal (Faculty of Arts and Sciences), and also at McGill University. Student life is extremely active at the IRCM, where weekly inter-lab meetings provide the opportunity for students to present their work, inciting multidisciplinary exchange among the different research groups.
We are presently looking for highly motivated M.Sc.
and Ph.D. students!
Arrival of Rathies Ravindra, trainee, on April 2022 and of Ali Genieyz, trainee, on May 2022.
May 2021 : Welcome to Océane Rondot, Jennifer Charles et Francis Desjardins who will spend 4 months in the laboratory as trainees.
January 2020 : Élodie Hardine is now making a Ph.D at Université de Montréal. She was also a trainee in Dr. Guindon's lab in 2018 (Sorbonne Université). Judith Boudrias, studying at Université de Sherbrooke, came for a 4 months' stage at Dr. Guindon's Lab. and Axelle Desriac (January - August 2020 ) is from Sorbonne Université. She is a trainee in the Lab. Welcome.
May 2019 to August 2029 : Arrival of Léa Théroux, trainee. Léa is from Université de Sherbrooke. Charles-HenriBuffet, trainee, (Sorbonne Université). Welcome to both of you.
January 2019 : Arrival of Carla Eymard, startiing her Ph.D. at Université de Montréal. Carla had been with us as a trainee earlier in 2018.
October 2018 : Welcome to Gang Wang, master's student, Renaud Zelli, postdoctoral fellow, Guillaume Michaud, master's student and Benjamin Gerlovin, trainee,
January-February 2018 : Welcome : Amarender Manchoju (Memorial University) postdoctoral fellow; Scott Foster,(University of Ottawa) coop student (4 months); Carla Eymard, (Université Pierre et Marie Curie) coop student (6 months).
May 2017: Welcome to Laura Jean (University of Ottawa) and Garrett Freure (also from University of Ottawa) who arrived this week for a period of 4 months as coop students.
July 2016 : Two of our proposals for grants were accepted by the Canadian Glycomics Network / Le réseau canadien de la glycomique. The first project - Spring 2015 "Development of Novel Selectins Antagonists for Vascular Diseases"; the second project - Fall 2015 "Cardioprotective Nucleosides for Chemothery. Great work ! Thanks to all of you.
June 2016 : At the 99th Canadian Chemistry Conference and Exhibition held in Halifax, Nova Scotia on June 5-9, 2016, Guillaume Tambutet gave a lecture entitled "Synthesis of a Novel Class of Nucleoside Analogues Bearing an All-Carbon Quaternary Center Targeting Solid Tumors". At this event, Starr Dostie gave also a lecture entitled "Diastereoselective Synthesis of Nucleoside Analogues via Cyclization of Acyclic Precursors".
Tommy Lussier who assisted at the Scientific Retreat of the IRCM gave a lecture entitled "Design of Novel Class of Nucleoside Analogues Displaying Anti-Cancer Activity". Marc-Olivier Labbé submitted a poster for the same event.
May 2016 : Dr. Guindon gave a presentation at the Canadian Glycomics Symposium, in Banff on May 16-20, 2016. The subject of his presentation was Selectin Antagonists. Louis Leblanc, a master'student in our lab, won the prize "Outstanding Poster Award" for his poster.
January 2016 : Welcome to Ryan Simard and Tommy Lussier who joined the lab as Master's students.
May 2015 : Welcome to Audrey Belouin and Marc-Olivier Labbé who started their master's degree.
December 1st, 2014 : Welcome to Laura Gillard who joined the group as Postdoc.
October 10, 2014 : Dr. Guindon gave a conference titled "From Free Radicals to Medicinal Chemistry" at the Max Malacria Symposium, Amphithéâtre Bilski-PasquierCliquez, Paris, France.
August 2014 : Welcome back to Tommy Lussier who joins the lab for the second time.
May 2014: Welcome to Audrey Bélouin, Marc-Olivier Labbé and Louis Leblanc who joined the group.
March 2014: Dr. Guindon gave a conference titled "From Free Radicals to Nucleosides Analogues" at the Institut de Chimie des Substances Naturelles, Paris, France, on the 13th of March 2014.
Februay 2014 : Dr. Guindon was nominated Fellow of the Amercian Association for the Advancement of Science (AAAS).
January 2014 : Welcome to Ryan Simard and Tommy Lussier in the Guindon's group.
October 2013 : Dr. Guindon gave a conference titled "Synthesis of Novel Bioactive Molecules, at the Institut Pasteur Korea, Séoul on the 28 of October 2013.
October 2013 : "Synthesis of Bioactive Agents using Free Radical Chemistry" is the title of the conference given by Dr. Guindon at the Shanghai Institute of Organic Chemistry of the Chinese Academy of Sciences in Shanghai.
June 2013 : New publications of the group on DFT studies were accepted : Diastereoselective Hydrogen-Transfer Reactions and a Study of Exocyclic Radical Reductions.
June 2013 : Professor Guindon gave a conference "Synthesis of Bioactive Molecules Using Free Radical Intermediates at the 6th Pacific Symposium on Radical Intermediates, Vancouver, BC., on the 18 of June 2013.
May 2013 : Congratulations to Starr for winning the Boerhinger Ingelhim first place for her poster during the IRCM research day.
May 2013 : Congratulations to Guillaume for giving an oral presentation during the Terry Fox Research Institue symposium.
May 2013 : Welcome to Carole-Ann and Louis in the Guindon group.
March 2013 : A new publication on nucleoside synthesis was accepted.
January 2013 : Conference "Recent trends in Organic Synthesis " Dr. Yvan Guindon at the American University of Beyrouth, Libanon.
January 2013 : Welcome to Ariana in the Guindon group.
November 2012 : Dr. Guindon gave a conference at the Mini Symposium ESPCI/ENSCP/Institut Curie in Paris on “Bioactive molecules synthesis”
November 2012 : Dr. Guindon gave a conference at Université de Laval à Québec on “Bioactive molecules synthesis”
November 2012 : Congratulations to Starr for passing her research proposal exam.
November 2012 : A new publication on polysaccharides synthesis was accepted.
October 2012 : Dr. Guindon visited the Chinese National Compound Library (CNCL), and gave two conferences :
September 2012 : A new publication about nucleoside analogue synthesis has been published in JOC (featured article).
July 2012 : Congratulations to Guillaume for passing his predoc exam.
June 2012 : Congratulations to Starr for winning an award at the IRCM research day.